This design research – in which lesson materials at the interface of arts, science and technology is going to be developed and implemented in group 5/6 of primary education and class 2 lower general secondary education – falls within the research theme ‘integrated education’ of the research group Leiderschap in Onderwijs en Opvoeding (Leadership in Education and Upbringing) of Windesheim Flevoland and the research theme ‘interdisciplinarity’ of the Arts Education Research Group of the Amsterdam University of the Arts (AHK). It is a follow-up research of the design research ‘Transdisciplinary design labs’ from 2017 by Groenendijk and Heijnen. This searched for new ways of making meaningful lesson materials at the interface of arts, technology and science, in which the key focus was on developing the 21st century skills creative thinking, solving problems, critical thinking and collaboration for pupils in secondary education. In this follow-up research, the theory from ‘Transdisciplinary design labs’ will be put into practice and the following research is the key focus: ‘In which ways can pupils develop 21st century skills while working on real-life, transdisciplinary problems at the interface of arts, science and technology?’